Julie Dalziel

Science Team Leader - Physiology & Health (Biological sciences)

Palmerston North, New Zealand

I lead research investigating mechanism of action of probiotics and food ingredients on physiology using animal, tissue, and cell models via membrane receptors. Through the Smarter Lives MBIE Endeavour Research programme we investigate the ability of dairy foods to influence behaviour via the gut-brain axis. We explore the taste attributes of fermented foods such as yogurt through interactions between fermentation-derived peptides and human taste receptors for kokumi, umami and sweet tastants.


  • Differences in peptide generation following in vitro gastrointestinal digestion of yogurt and milk from cow, sheep and goat
  • The Role of the Gut Microbiota in Dietary Interventions for Depression and Anxiety
  • Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins
  • Differential effects of sheep and cow skim milk before and after fermentation on gastrointestinal transit of solids in a rat model
  • The Role of Intestinal Barrier Function in the Development of Colitis
  • Mutating the highly conserved second membrane-spanning region 9' leucine residue in the α1 or β1 subunit produces subunit-specific changes in the function of human α1β1 γ-aminobutyric acid(A) receptors
  • Porous materials to support bilayer lipid membranes for ion channel biosensors
  • Bio-activity of catechin and chlorogenic acid on the cellular response to oxidative stress: A role for microRNA regulation of the response?
  • Gastric emptying and gastrointestinal transit compared among native and hydrolyzed whey and casein milk proteins in an aged rat model
  • The Effects of Unfermented and Fermented Cow and Sheep Milk on the Gut Microbiota
  • Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin
  • Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model
  • Investigation of free amino acids in lactic acid bacteria fermented milk and their ability to activate the calcium sensing receptor
  • Combined effects of fungal alkaloids on intestinal motility in an in vitro rat model
  • Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction
  • G Protein-Coupled Receptors in Taste Physiology and Pharmacology
  • The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress
  • Generation and identification of kokumi compounds and their validation by taste-receptor assay: An example with dry-cured lamb meat
  • Short communication: Processed bovine colostrum milk protein concentrate increases epithelial barrier integrity of Caco-2 cell layers
  • Towards an understanding of the structural basis for insect olfaction by odorant receptors
  • BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo
  • A structural determinant of desensitization and allosteric regulation by pentobarbitone of the GABA(A) receptor
  • An in vitro rat model of colonic motility to determine the effect of β-casomorphin-5 on propagating contractions
  • HERG ion channel pharmacology: Cell membrane liposomes in porous-supported lipid bilayers compared with whole-cell patch-clamping
  • Molecular divergence of two orthologous scorpion toxins affecting potassium channels
  • The probiotic Escherichia coli Nissle 1917 inhibits propagating colonic contractions in the rat isolated large intestine
  • Mechanism of action of lolitrem B, a fungal endophyte derived toxin that inhibits BK large conductance Ca2+-activated K+ channels
  • Bilayer lipid membranes supported on Teflon filters: A functional environment for ion channels
  • A role for BK channels in heart rate regulation in rodents
  • Structural determinants of lolitrems for inhibition of BK large conductance Ca2+-activated K+ channels
  • The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels
  • Chapter Two Rapid Purification and Reconstitution of Recombinant Voltage-Gated Sodium Channels into Planar BLMs
  • Expression of human BK ion channels in Sf9 cells, their purification using metal affinity chromatography, and functional reconstitution into planar lipid bilayers
  • Recombinant human voltage-gated skeletal muscle sodium channels are pharmacologically functional in planar lipid bilayers
  • The fungal neurotoxin lolitrem B inhibits the function of human large conductance calcium-activated potassium channels
  • Penicillin blocks human α1β1 and α1β1γ2S GABAA channels that open spontaneously
  • Mutant human α1β1(T262Q) GABA(A) receptors are directly activated but not modulated by pentobarbital
  • A threonine residue in the M2 region of the β1 subunit is needed for expression of functional α1β1 GABA(A) receptors
  • Tracking gastrointestinal transit of solids in aged rats as pharmacological models of chronic dysmotility
  • Gastroparesis and lipid metabolism-associated dysbiosis in Wistar-Kyoto rats
  • Promotility action of the probiotic Bifidobacterium lactis HN019 extract compared with prucalopride in isolated rat large intestine
  • Influence of bovine whey protein concentrate and hydrolysate preparation methods on motility in the isolated rat distal colon
  • Alteration in propagating colonic contractions by dairy proteins in isolated rat large intestine
  • Goat milk increases gastric emptying and alters caecal short chain fatty acid profile compared with cow milk in healthy rats
  • Microbial signalling in colonic motility
  • A Diet Enriched with Lacticaseibacillus rhamnosus HN001 and Milk Fat Globule Membrane Alters the Gut Microbiota and Decreases Amygdala GABA a Receptor Expression in Stress-Sensitive Rats
  • Anxiety-like Behavior in Female Sprague Dawley Rats Associated with Cecal Clostridiales

Julie Dalziel's public data