Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model
journal contribution
posted on 2023-06-18, 21:03 authored by Nabil Parkar, Julie DalzielJulie Dalziel, Nick J. Spencer, Patrick Janssen, Warren McNabb, Wayne YoungThis study explores how slowed gastrointestinal transit (constipation) induced by the opioid agonist loperamide (imodium) alters the microbiota composition such that the richness and diversity of the bacterial communities is lowered. Notably Bacteroides were relatively abundant in the loperamide treated group suggesting that slowed colonic transit facilitates the amplification and colonization of genera such as Bacteroides that adapt well in slow moving and competitive environments with limited resources.
Funding
Smarter Lives: New opportunities for dairy products across the lifespan
Ministry of Business, Innovation and Employment
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Rights statement
© 2023 Parkar, Dalziel, Spencer, Janssen, McNabb and Young. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Publication date
2023-03-14Project number
- 11600
Language
- English
Does this contain Māori information or data?
- No
