Ferguson-and-Barnett_IJMS2016.pdf (1.62 MB)

Why are omics technologies important to understanding the role of nutrition in inflammatory bowel diseases?

Download (1.62 MB)
journal contribution
posted on 2023-05-03, 16:22 authored by Lynnette Ferguson, Matthew BarnettMatthew Barnett
For many years, there has been confusion about the role that nutrition plays in inflammatory bowel diseases (IBD). It is apparent that good dietary advice for one individual may prove inappropriate for another. As with many diseases, genome-wide association studies across large collaborative groups have been important in revealing the role of genetics in IBD, with more than 200 genes associated with susceptibility to the disease. These associations provide clues to explain the differences in nutrient requirements among individuals. In addition to genes directly involved in the control of inflammation, a number of the associated genes play roles in modulating the gut microbiota. Cell line models enable the generation of hypotheses as to how various bioactive dietary components might be especially beneficial for certain genetic groups. Animal models are necessary to mimic aspects of the complex aetiology of IBD, and provide an important link between tissue culture studies and human trials. Once we are sufficiently confident of our hypotheses, we can then take modified diets to an IBD population that is stratified according to genotype. Studies in IBD patients fed a Mediterranean-style diet have been important in validating our hypotheses and as a proof-of-principle for the application of these sensitive omics technologies to aiding in the control of IBD symptoms.


Rights statement

© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (


  • English

Does this contain Māori information or data?

  • No



Journal title

International Journal of Molecular Sciences




Ferguson, L. R., & Barnett, M. P. G. (2016). Why are omics technologies important to understanding the role of nutrition in inflammatory bowel diseases? International Journal of Molecular Sciences, 17(10), 1763. doi:10.3390/ijms17101763

Usage metrics


    Ref. manager