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ORS 9545-Nutrients 11_7_1636 - AShrestha et al 170719.pdf (592.97 kB)

Validity of a portable breath analyser (AIRE) for the assessment of lactose malabsorption

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posted on 2023-05-03, 18:24 authored by Aahana Shrestha, Utpal Prodhan, Sarah Mitchell, Pankaja Sharma, Matthew BarnettMatthew Barnett, Amber MilanAmber Milan, David Cameron-Smith
Hydrogen (H2) measurement in exhaled breath is a reliable and non-invasive method to diagnose carbohydrate malabsorption. Currently, breath H2 measurement is typically limited to clinic-based equipment. A portable breath analyser (AIRE, FoodMarble Digestive Health Limited, Dublin, Ireland) is a personalised device marketed for the detection and self-management of food intolerances, including lactose malabsorption (LM). Currently, the validity of this device for breath H2 analysis is unknown. Individuals self-reporting dairy intolerance (six males and six females) undertook a lactose challenge and a further seven individuals (all females) underwent a milk challenge. Breath samples were collected prior to and at frequent intervals post-challenge for up to 5 h with analysis using both the AIRE and a calibrated breath hydrogen analyser (BreathTracker, QuinTron Instrument Company Inc., Milwaukee, WI, USA). A significant positive correlation (p < 0.001, r > 0.8) was demonstrated between AIRE and BreathTracker H2 values, after both lactose and milk challenges, although 26% of the AIRE readings demonstrated the maximum score of 10.0 AU. Based on our data, the cut-o value for LM diagnosis (25 ppm H2) using AIRE is 3.0 AU and it is e ective for the identification of a response to lactose-containing foods in individuals experiencing LM, although its upper limit is only 81 ppm.

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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

MDPI

Journal title

Nutrients

ISSN

2072-6643

Citation

Shrestha, A., Prodhan, U. K., Mitchell, S. M., Sharma, P., Barnett, M. P. G., Milan, A. M., & Cameron-Smith, D. (2019). Validity of a portable breath analyser (AIRE) for the assessment of lactose malabsorption. Nutrients, 11, 1636. doi:10.3390/nu11071636

Contract number

A22667

Job code

11883

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