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The local regulation of folliculogenesis by members of the transforming growth factor superfamily and its relevance for advanced breeding programmes

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Regulation of the growth and maturation of the ovarian follicle is critical for normal reproductive function. Alterations in this growth can lead to pathological conditions, such as cystic follicles, reduced oocyte quality, or an abnormal endocrine environment leading to poor fertility. Alterations in follicular growth also influence the number of follicles ovulating and thus can change litter size. Both endocrine factors, such as follicle stimulating hormone and luteinizing hormone, as well as local factors, are known to regulate follicular growth and development. This review will focus on the role of local factors in regulation of ovarian follicular growth in ruminants, with a focus on members of the transforming growth factor superfamily. The potential role of these factors in regulating proliferation, apoptosis, steroidogenesis and responsiveness to gonadotrophins will be considered.

History

Rights statement

Anim Reprod @2018 All rights reserved.

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

Brazilian College of Animal Reproduction

Journal title

Animal Reproduction

ISSN

1984-3143

Citation

Juengel, J. L., Smith, P. R., Quirke, L. D., French, M. C., & Edwards, S. J. (2018). The local regulation of folliculogenesis by members of the transforming growth factor superfamily and its relevance for advanced breeding programmes. Animal Reproduction, 15(3), 180–190. doi:10.21451/1984-3143-AR2018-0055

Funder

Core Funding

Contract number

A22695

Job code

35000

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