the-kinetics-of-amino-acid-disappearance-in-the-small-intestine-is-related-to-the-extent-of-amino-acids-absorbed-in-growing-pigs.pdf (410.14 kB)

The kinetics of amino acid disappearance in the small intestine is related to the extent of amino acids absorbed in growing pigs

Download (410.14 kB)
journal contribution
posted on 2024-06-20, 01:55 authored by Carlos MontoyaCarlos Montoya, Michael van Bemmel, Kevin Kreutz, Suzanne Hodgkinson, Natascha Stroebinger, Paul Moughan

This study evaluated the importance of a correction for amino acids (AA) released into the hindgut on a measure of AA absorption kinetics and tested whether AA absorption kinetics are related to the extent of AA absorption using the growing pig as a model for humans. Thirty-six nine-week-old pigs (22·3 kg) received a diet containing whey protein as the sole protein source for 8 d. Pigs received their last meal containing the indigestible marker titanium dioxide before being euthanised at 1, 2, 3, 4, 6 and 12 h post-feeding. The entire content of each gastrointestinal tract (GIT) region was collected to determine AA released into the hindgut, and the kinetics and extent of AA absorption (uncorrected and corrected for AA entering the hindgut). Amounts of AA released into the hindgut increased over time (e.g. 33 and 180 mg of Glu for 4 and 6 h post-feeding). The corrected apparent amount of each AA absorbed from the GIT lumen after 4 h post-feeding was generally lower (P ≤ 0·05) than the uncorrected counterpart. Differences in both the kinetics and extent of AA absorption were observed across AA. For example, the time to reach half of the apparent AA absorption (T50) was 1·5 and 3·4 h for Met and Arg, respectively, whereas their extent of apparent absorption was 93 and 73 %. Negative correlations between parameters related to kinetics and the extent of apparent absorption were observed (e.g. for T50 r = −0·81; P < 0·001). The kinetics of AA absorption is related to the extent of AA absorption.


AgResearch Strategic Science Investment Fund, contract A25773 (Systems Nutrition for Consumer Wellbeing)


Rights statement

© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.

Publication date


Project number

  • Non revenue


  • English

Does this contain Māori information or data?

  • No


Cambridge University Press

Journal title

British Journal of Nutrition



Volume/issue number


Page numbers

762 - 772

Usage metrics



    Ref. manager