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FBP 45183 Nutrients 6(11) 4839-4855 - McCann et al 031114.pdf (870.16 kB)

The anti-proliferative effects of enterolactone in prostate cancer cells: Evidence for the role of DNA licencing genes, mi-R106b cluster expression, and PTEN dosage

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posted on 2023-05-03, 11:24 authored by Mark McCann, Ian Rowland, Nicole Roy
The mammalian lignan, enterolactone, has been shown to reduce the proliferation of the earlier stages of prostate cancer at physiological concentrations in vitro. However, efficacy in the later stages of the disease occurs at concentrations difficult to achieve through dietary modification. We have therefore investigated what concentration(s) of enterolactone can restrict proliferation in multiple stages of prostate cancer using an in vitro model system of prostate disease. We determined that enterolactone at 20 μM significantly restricted the proliferation of mid and late stage models of prostate disease. These effects were strongly associated with changes in the expression of the DNA licencing genes (GMNN, CDT1, MCM2 and 7), in reduced expression of the miR-106b cluster (miR-106b, miR-93, and miR-25), and in increased expression of the PTEN tumour suppressor gene. We have shown anti-proliferative effects of enterolactone in earlier stages of prostate disease than previously reported and that these effects are mediated, in part, by microRNA-mediated regulation.

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Rights statement

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal title

Nutrients

ISSN

2072-6643

Citation

McCann, M.J., Rowland, I.R., & Roy, N.C. (2014). The anti-proliferative effects of enterolactone in prostate cancer cells: Evidence for the role of DNA licencing genes, mi-R106b cluster expression, and PTEN dosage. Nutrients, 6(11), 4839-4855

Contract number

A21483

Job code

11352

Report number

FBP 45153||FBP 23257

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