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Ruminant milk-derived extracellular vesicles: A nutritional and therapeutic opportunity?

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posted on 2023-05-03, 19:29 authored by Siew Ling Ong, Cherie Blenkiron, Stephen HainesStephen Haines, Alejandra Acevedo-Fani, Juliana Leite, Janos Zempleni, Rachel AndersonRachel Anderson, Mark McCann
Milk has been shown to contain a specific fraction of extracellular particles that are reported to resist digestion and are purposefully packaged with lipids, proteins, and nucleic acids to exert specific biological effects. These findings suggest that these particles may have a role in the quality of infant nutrition, particularly in the early phase of life when many of the foundations of an infant’s potential for health and overall wellness are established. However, much of the current research focuses on human or cow milk only, and there is a knowledge gap in how milk from other species, which may be more commonly consumed in different regions, could also have these reported biological effects. Our review provides a summary of the studies into the extracellular particle fraction of milk from a wider range of ruminants and pseudo-ruminants, focusing on how this fraction is isolated and characterised, the stability and uptake of the fraction, and the reported biological effects of these fractions in a range of model systems. As the individual composition of milk from different species is known to differ, we propose that the extracellular particle fraction of milk from non-traditional and minority species may also have important and distinct biological properties that warrant further study.

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© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

MDPI

Journal title

Nutrients

ISSN

2072-6643

Citation

Ong, S. L., Blenkiron, C., Haines, S., Acevedo-Fani, A., Leite, J. A. S., Zempleni, J., … McCann, M. J. (2021). Ruminant milk-derived extracellular vesicles: A nutritional and therapeutic opportunity? Nutrients, 13(8), 2505. doi:10.3390/nu13082505

Job code

PRJ0056239

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