Front Immunol_12_765528_ACait et al 171121.pdf (4.02 MB)

Potential association between dietary fibre and humoral response to the seasonal influenza vaccine

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journal contribution
posted on 2023-05-03, 18:48 authored by Alissa Cait, Anna Mooney, Hazel Poyntz, Nick Shortt, Angela Jones, Aurelie Gestin, Katie Gell, Alix Grooby, David O’Sullivan, Jeffry Tang, Wayne Young, Darmiga Thayabaran, Jenny Sparks, Tess Ostapowicz, Audrey Tay, Sally Poppitt, Sarah Elliott, Georgia Wakefield, Amber Parry-Strong, Jacqui Ralston, Richard Beasley, Mark Weatherall, Irene Braithwaite, Elizabeth Forbes-Blom, Olivier Gasser
Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral vaccine responses. We found dietary fibre intake and the abundance of fibre-fermenting intestinal bacteria to be positively correlated with humoral influenza vaccine-specific immune responses in human vaccinees, albeit without reaching statistical significance. Importantly, this correlation was largely driven by first-time vaccinees; prior influenza vaccination negatively correlated with vaccine immunogenicity. In support of these observations, dietary fibre consumption significantly enhanced humoral influenza vaccine responses in mice, where the effect was mechanistically linked to short-chain fatty acids, the bacterial fermentation product of dietary fibre. Overall, these findings may bear significant importance for emerging infectious agents, such as COVID-19, and associated de novo vaccinations.


Rights statement

© 2021 Cait, Mooney, Poyntz, Shortt, Jones, Gestin, Gell, Grooby, O’Sullivan, Tang, Young, Thayabaran, Sparks, Ostapowicz, Tay, Poppitt, Elliott, Wakefield, Parry-Strong, Ralston, Beasley, Weatherall, Braithwaite, Forbes-Blom and Gasser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.


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Journal title

Frontiers in Immunology.




Cait, A., Mooney, A., Poyntz, H., Shortt, N., Jones, A., Gestin, A., Gell, K., Grooby, A., O’Sullivan, D., Tang, J. S., Young, W., Thayabaran, D., Sparks, J., Ostapowicz, T., Tay, A., Poppitt, S. D., Elliott, S., Wakefield, G., Parry-Strong, A., Ralston, J., Beasley, R., Weatherall, M., Braithwaite, I., Forbes-Blom, E., & Gasser, O. (2021). Potential association between dietary fibre and humoral response to the seasonal influenza vaccine. Frontiers in Immunology., 12, 765528.

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