AgResearch
Browse
nzac082.pdf (1.55 MB)

Plasma amino acid appearance and status of appetite following a single meal of red meat or a plant-based meat analog: A randomized crossover clinical trial

Download (1.55 MB)
journal contribution
posted on 2023-05-03, 22:14 authored by Toan Pham, Scott KnowlesScott Knowles, Emma Bermingham, Julie Brown, Rina HannafordRina Hannaford, David Cameron-Smith, Andrea Braakhuis
Background Red meat is a nutrient-dense food and a dietary staple. A new generation of plant-based meat analogs (PBMAs) have been designed to mimic the experience of eating meat, but there is limited evidence about their digestive efficacy and nutritional quality. Objectives We compared the postprandial digestive response of a single meal containing meat commercially raised in New Zealand, including lamb, on-farm pasture-raised beef (Pasture), or grain-finished beef (Grain) with a PBMA (Beyond Burger; Beyond Meat) sold through consumer retail. The primary outcome was the appearance of amino acids in plasma. Secondary outcomes included glucose and insulin, appetite assessment, and anthropometry. Methods Thirty healthy men (20–34 y) participated in a double-blinded randomized crossover trial. Each consumed 1 of the 4 test meals on 4 occasions separated by a washout period of at least 1 wk, following an overnight fast. The meal was a burrito-style wrap containing meat or PBMAs, vegetables, salsa, and seasonings in a flour tortilla. The amount of Pasture, Grain, Lamb, or BB was 220 g raw (∼160 g cooked). Venous blood samples were collected over 4 h. Appetite and hunger status was scored with visual analog scales. Results Pre-meal amino acid concentrations in plasma did not differ by group (P > 0.9), although several nonessential amino acids differed strongly according to participant BMI. Postprandial amino acids peaked at 2–3 h in all groups. The BB meal produced significantly lower plasma concentrations of total, essential, branched-chain, and non-proteogenic amino acids than the Lamb, Pasture, or Grain meals, based on AUC. There were no significant differences between meal groups in scores for hunger, fullness, or cravings. Conclusions Red meat meals exhibited greater bioavailability of amino acids compared with the PBMA (BB). Pasture versus Grain origins of the beef had little influence on participants’ responses. This trial was registered at ClinicalTrials.gov as NCT04545398.

History

Rights statement

© The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

Oxford University Press

Journal title

Current Developments in Nutrition

ISSN

2475-2991

Citation

Pham, T., Knowles, S., Bermingham, E., Brown, J., Hannaford, R., Cameron-Smith, D., & Braakhuis, A. (2022). Plasma amino acid appearance and status of appetite following a single meal of red meat or a plant-based meat analog: A randomized crossover clinical trial. Current Developments in Nutrition, 6(5), nzac082. https://doi.org/10.1093/cdn/nzac082

Funder

Ministry of Business, Innovation and Employment (MBIE)||Meat Industry Association Innovation Limited (MIAI)||Beef + Lamb New Zealand

Usage metrics

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC