posted on 2023-05-03, 15:34authored byAndrew Selwood, Alistair Wilkins, Rex Munday, Haifeng Gu, Kirsty Smith, Lesley Rhodes, Frode Rise
Pinnatoxin H was isolated from a culture of the dinoflagellate Vulcanodinium rugosum isolated from the South China Sea. The structure of pinnatoxin H was elucidated by LC–MS/MS and NMR spectroscopy. It was found to have the same macrocyclic structure and substituents as pinnatoxins D, E and F, but the side chain on the cyclohexenyl ring was an ethenyl group, as found in pinnatoxin G and portimine. The observation that this strain of V. rugosum produced only pinnatoxin H and portimine is consistent with previous findings that the profile of pinnatoxins can vary significantly among strains. The acute toxicity of pinnatoxin H to mice was 67 lg/kg (intraperitoneal) and 163 lg/kg (gavage).
Selwood, A. I., Wilkins, A. L., Munday, R., Gu, H., Smith, K. F., Rhodes, L. L., & Rise, F. (2014). Pinnatoxin H: a new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate. Tetrahedron Letters, 55(40), 5508-5510.