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Oral administration of heat-killed Lactobacillus brevis KB290 in combination with retinoic acid provides protection against influenza virus infection in mice

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posted on 2023-05-03, 21:00 authored by Shohei Satomi, Sofia KhanumSofia Khanum, Poppy Miller, Shigenori Suzuki, Hiroyuki Suganuma, Axel HeiserAxel Heiser, Sandeep GuptaSandeep Gupta
Influenza virus type A (IAV) is a seasonal acute respiratory disease virus with severe symptoms, and an effective preventive measure is required. Despite many reports describing the potentially protective effects of lactic acid bacteria, few studies have investigated the effects of nutritional supplement combinations. This study reports the effect of the combined intake of heat-killed Lactobacillus brevis KB290 (KB290) and vitamin A (VA) on mice challenged with a sublethal dose of IAV. For 2 weeks, five groups of mice were fed either placebo, KB290, VA, or a combination of KB290 and VA (KB290+VA). After subsequent IAV challenge, bodyweight and general health were monitored for up to 2 weeks. Viral titres were determined in the lungs of animal subgroups euthanised at days 3, 7, and 14 after IAV challenge. A significant loss was observed in the bodyweights of IAV-infected animals from day 1 post-IAV challenge, whereas the mice fed KB290+VA did not lose any weight after IAV infection, indicating successful protection from the infection. Additionally, mice in the KB290+VA group showed the highest reduction in lung viral titres. In conclusion, the combination of KB290 and VA could be a useful food supplement relevant for protection against seasonal influenza virus infection in humans.

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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

MDPI

Journal title

Nutrients

ISSN

2072-6643

Citation

Satomi, S., Khanum, S., Miller, P., Suzuki, S., Suganuma, H., Heiser, A., & Gupta, S. K. (2020). Oral administration of heat-killed Lactobacillus brevis KB290 in combination with retinoic acid provides protection against influenza virus infection in mice. Nutrients, 12(10), 2925.

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