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Modeling the effect of insulin-like growth factor-1 on human cell growth

journal contribution
posted on 2023-05-03, 16:20 authored by Gemma Phillips, Paul ShortenPaul Shorten, Graeme Wake, Jian Guan
Insulin-like growth factor-1 (IGF-1) plays a key role in human growth and development. The interactions of IGF-1 with IGF-1 receptors and IGF-1 binding proteins (IGFBPs) regulate IGF-1 function. Recent research suggests that a metabolite of IGF-1, cyclo-glycyl-proline (cGP), has a role in regulating IGF-1 homeostasis. A component of this interaction is believed to be the competitive binding of IGF-1 and cGP to IGFBPs. In this paper we describe a mathematical model of the interaction between IGF-1 and cGP on human cell growth. The model can be used to understand the interaction between IGF-1, IGFBPs, cGP and IGF-1 receptors along with the kinetics of cell growth. An explicit model of the known interactions between IGF-1, cGP, IGFBPs, IGF-1 receptors explained a large portion of the variance in cell growth (R2 = 0.83). An implicit model of the interactions between IGF-1, cGP, IGFBPs, IGF-1 receptors that included a hypothesized feedback of cGP on IGF-1 receptors explained nonlinear features of interaction between IGF-1 and cGP not described by the explicit model (R2 = 0.84). The model also explained the effect of IGFBP antibody on the interaction between cGP and IGF-1 (R2 = 0.78). This demonstrates that the competitive binding of IGF-1 and cGP to IGFBPs plays a large role in the interaction between IGF-1 and cGP, but that other factors potentially play a role in the interaction between cGP and IGF-1. These models can be used to predict the complex interaction between IGF-1 and cGP on human cell growth and form a basis for further research in this field.

History

Rights statement

© 2014ElsevierInc.Allrightsreserved.

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

Elsevier

Journal title

Mathematical Biosciences

ISSN

0025-5564

Citation

Phillips, G. M. A., Shorten, P. R., Wake, G. C., & Guan, J. (2015). Modeling the effect of insulin-like growth factor-1 on human cell growth. Mathematical Biosciences, 259, 43–54. doi:10.1016/j.mbs.2014.11.002

Funder

Massey University||Ministry of Business Innovation & Employment

Contract number

A13953

Job code

55854

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