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Lipidomics of brain tissues in rats fed human milk from Chinese mothers or commercial infant formula

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posted on 2023-05-03, 21:59 authored by Miya Su, Arvind SubbarajArvind Subbaraj, Karl FraserKarl Fraser, Xiaoyan Qi, Hongxin Jia, Wenliang Chen, Mariza Gomes Reis, Michael AgnewMichael Agnew, Li DayLi Day, Nicole Roy, Wayne Young
Holistic benefits of human milk to infants, particularly brain development and cognitive behavior, have stipulated that infant formula be tailored in composition like human milk. However, the composition of human milk, especially lipids, and their effects on brain development is complex and not fully elucidated. We evaluated brain lipidome profiles in weanling rats fed human milk or infant formula using non-targeted UHPLC-MS techniques. We also compared the lipid composition of human milk and infant formula using conventional GC-FID and HPLC-ELSD techniques. The sphingomyelin class of lipids was significantly higher in brains of rats fed human milk. Lipid species mainly comprising saturated or mono-unsaturated C18 fatty acids contributed significantly higher percentages to their respective classes in human milk compared to infant formula fed samples. In contrast, PUFAs contributed significantly higher percentages in brains of formula fed samples. Differences between human milk and formula lipids included minor fatty acids such as C8:0 and C12:0, which were higher in formula, and C16:1 and C18:1 n11, which were higher in human milk. Formula also contained higher levels of low- to medium-carbon triacylglycerols, whereas human milk had higher levels of high-carbon triacylglycerols. All phospholipid classes, and ceramides, were higher in formula. We show that brain lipid composition differs in weanling rats fed human milk or infant formula, but dietary lipid compositions do not necessarily manifest in the brain lipidome.

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Rights statement

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

MDPI

Journal title

Metabolites

ISSN

2218-1989

Citation

Su, M., Subbaraj, A. K., Fraser, K., Qi, X., Jia, H., Chen, W., … Young, W. (2019). Lipidomics of brain tissues in rats fed human milk from Chinese mothers or commercial infant formula. Metabolites, 9(11), 253. doi:10.3390/metabo9110253

Funder

Bright Dairy & Food Co Ltd

Contract number

A23596

Job code

11583

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