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Interactions between allogeneic mesenchymal stromal cells and the recipient immune system: A comparative review with relevance to equine outcomes

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posted on 2023-05-03, 20:40 authored by Lacy Kamm, Christopher Riley, Natalie ParlaneNatalie Parlane, Erica Gee, Wayne McIlwraith
Despite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient. In naïve recipients, this immune response is initially driven by the innate immune system, an immediate reaction to the foreign cells, and later, the adaptive immune system, a delayed response that causes cell death due to recognition of specific alloantigens by host cells and antibodies. This review describes the actions of MSCs to both suppress and activate the different arms of the immune system. We then review the survival and effectiveness of the currently used allogeneic MSC treatments.

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Rights statement

Copyright © 2021 Kamm, Riley, Parlane, Gee and McIlwraith. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

Frontiers Media S.A.

Journal title

Frontiers in Veterinary Science

ISSN

2297-1769

Citation

Kamm, J. L., Riley, C. B., Parlane, N., Gee, E. K., & McIlwraith, C. W. (2021). Interactions between allogeneic mesenchymal stromal cells and the recipient immune system: A comparative review with relevance to equine outcomes. Frontiers in Veterinary Science, 7, 617647. https://doi.org/10.3389/fvets.2020.617647

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