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Gut-brain axis in the early postnatal years of life: A developmental perspective

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posted on 2023-05-03, 09:47 authored by Ankita Jena, Carlos MontoyaCarlos Montoya, Jane MullaneyJane Mullaney, Ryan Dilger, Wayne Young, Warren McNabb, Nicole Roy
In the first two to three years of life, the development of the gastrointestinal (GI) tract and the brain in humans occurs in parallel. Emerging evidence suggests that alterations in the development of GI tract during this critical period can influence brain development and vice-versa. It is increasingly recognized that communication between the GI tract and brain is mainly driven by neural, endocrine, immune, and metabolic mediators, collectively called the gut-brain axis (GBA). However, it is unclear whether changes during the early-postnatal period in the GBA also occur in response to the parallel development of the GI tract and brain. This review summarizes the communication between the GI tract and brain in response to their development in the early postnatal period.


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Copyright © 2020 Jena, Montoya, Mullaney, Dilger, Young, McNabb and Roy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.


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Frontiers Media

Journal title

Frontiers in Integrative Neuroscience




Jena, A., Montoya, C. A., Mullaney, J. A., Dilger, R. N., Young, W., McNabb, W. C., & Roy, N. C. (2020). Gut-brain axis in the early postnatal years of life: A developmental perspective. Frontiers in Integrative Neuroscience, 14, 44. doi:10.3389/fnint.2020.00044

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