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Glycan utilisation and function in the microbiome of weaning infants

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posted on 2023-05-03, 18:15 authored by Starin McKeen, Wayne Young, Karl FraserKarl Fraser, Nicole Roy, Warren McNabb
Glycans are present exogenously in the diet, expressed and secreted endogenously by host cells, and produced by microbes. All of these processes result in them being available to the gut microbiome, firmly placing glycans at the interface of diet–microbe–host interactions. The most dramatic shift in dietary sources of glycans occurs during the transition from the milk-based neonatal diet to the diverse omnivorous adult diet, and this has profound effects on the composition of the gut microbiome, gene expression by microbes and host cells, mucin composition, and immune development from innate towards adaptive responses. Understanding the glycan-mediated interactions occurring during this transitional window may inform dietary recommendations to support gut and immune development during a vulnerable age. This review aims to summarise the current state of knowledge on dietary glycan mediated changes that may occur in the infant gut microbiome and immune system during weaning.

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Rights statement

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

MDPI

Journal title

Microorganisms

ISSN

2076-2607

Citation

McKeen, S., Young, W., Fraser, K., Roy, N. C., & McNabb, W. C. (2019). Glycan utilisation and function in the microbiome of weaning infants. Microorganisms, 7(7), 190. doi:10.3390/microorganisms7070190

Funder

University of Auckland

Contract number

A24055

Job code

11545

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