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Genome wide association study for growth in Pakistani dromedary camels using genotyping-by-sequencing.pdf (1.76 MB)

Genome wide association study for growth in Pakistani dromedary camels using genotyping-by-sequencing

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posted on 2023-07-21, 02:45 authored by Sajida Sabahat, Asif Nadeem, Rudiger BrauningRudiger Brauning, Peter Thomson, Mehar Khatkar

Objective: Growth performance and growth-related traits have a crucial role in livestock due to their influence on productivity. This genome-wide association study (GWAS) in Pakistani dromedary camels was conducted to identify single nucleotide polymorphisms (SNPs) associated with growth at specific camel ages, and for selected SNPs, to investigate in detail how their effects change with increasing camel age. This is the first GWAS conducted on dromedary camels in this region.

Methods: Two Pakistani breeds, Marecha and Lassi, were selected for this study. A genotypingby-sequencing method was used, and a total of 65,644 SNPs were identified. For GWAS, weight records data with several body weight traits, namely, birthweight, weaning weight, and weights of camels at 1, 2, 4, and 6 years of age were analysed by using model-based growth curve analysis. Age-specific weight data were analysed with a linear mixed model that included fixed effects of SNP genotype as well as sex.

Results: Based on the q-value method for false discovery control, for Marecha camels, five SNPs at q<0.01 and 96 at q<0.05 were significantly associated with the weight traits considered, while three (q<0.01) and seven (q<0.05) SNP associations were identified for Lassi camels. Several candidate genes harbouring these SNP were discovered.

Conclusion: These results will help to better understand the genetic architecture of growth including how these genes are expressed at different phases of their life. This will serve to lay the foundations for applied breeding programs of camels by allowing the genetic selection of superior animals.

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Copyright © 2023 by Animal Bioscience. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Publication date

2022-11-14

Project number

  • 49050x01

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

Asian-Australasian Association of Animal Production Societies

Journal title

Animal Bioscience

ISSN

2765-0189

Volume/issue number

36/7

Page numbers

1010-1021

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