Effects of sporidesmin on cultured biliary tract cells from Romney lambs that differed in their sensitivity to sporidesmin

AIMS The aims of this research were (1) to establish cell cultures that could be used to 40 examine the cellular effects of the facial eczema toxin sporidesmin, and (2) to investigate differences among cells from lines of Romney lambs that had been selected for resistance or sensitivity to the toxin. The cultures were established from the epithelial surfaces of gallbladder walls because of the effects of sporidesmin on the biliary tract in vivo, which is a likely primary effect of the toxin.