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Dietary supplementation of SAT and SANT, New Zealand deer velvet supplements, halts systemic LPS-induced neuroinflammation and sickness behaviour in mice

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posted on 2024-07-28, 21:43 authored by Carol ThumCarol Thum, Axel HeiserAxel Heiser, Paul MacleanPaul Maclean, Rina HannafordRina Hannaford, Andrew Clarkson

Deer velvet extracts' anti-inflammatory and immune-modulatory effects have been widely demonstrated. However, the effects of deer velvet extracts on neuroinflammation and sickness behaviour have only been suggested. This study aimed to test the effect of two deer velvet supplements, SAT and SANT, on preventing LPS-induced systemic inflammation, neuroinflammatory changes and sickness behaviour in mice. Mice diet was supplemented (4 mg/kg/day) with either SAT or SANT or given normal chow as a control for four weeks before receiving a single dose of either LPS (1 mg/kg) or saline. Velvet supplements reduced sickness scores at 6 and 12 h, but not mice activity as measured by open field test at 24 h after LPS injection. Velvet supplements did not affect plasma cytokines but prevented the overexpression of brain inflammation genes and reduced microglial reactivity after 24 h of LPS injection. Results indicate that SAT and SANT modulate sickness behaviour during peak LPS effects and brain inflammation after 24 h of injections through different pathways.

Funding

AgResearch Limited SSIF (PRJ0450290)

Deer Industry New Zealand

History

Rights statement

© 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).

Publication date

2024-05-03

Project number

  • PRJ0450290

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

Elsevier

Journal title

Journal of functional foods

ISSN

1756-4646

Volume/issue number

116

Page numbers

106225

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