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DNA methylation networks underlying mammalian traits

journal contribution
posted on 2023-09-25, 02:41 authored by Amin Haghani, Caesar Li, Ake Lu, Alex CaultonAlex Caulton, Shannon ClarkeShannon Clarke, Steve Horvath

This article has 190 Authors.

Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in HOXL subclass homeobox genes and developmental processes and is potentially regulated by pluripotency transcription factors. The methylation state of some modules responds to perturbations such as caloric restriction, ablation of growth hormone receptors, consumption of high-fat diets, and expression of Yamanaka factors. This study reveals an intertwined evolution of the genome and epigenome that mediates the biological characteristics and traits of different mammalian species.


History

Rights statement

Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.

Publication date

2023-08-11

Project number

  • Non revenue

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

American Association for the Advancement of Science

Journal title

Science

ISSN

0036-8075

Volume/issue number

381(6658)

Page numbers

eabq5693

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