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Comparison of the acute postprandial circulating B-vitamin and vitamer responses to single breakfast meals in young and older individuals: preliminary secondary outcomes of a randomized controlled trial

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posted on 2023-05-03, 18:12 authored by Pankaja Sharma, Nicola Gillies, Shikha Pundir, Chantal Pileggi, James Markworth, Eric Thorstensen, David Cameron-Smith, Amber MilanAmber Milan
B-vitamin deficiency is common in ageing populations either due to altered dietary habits or altered digestive and metabolic functions. There is limited data on the acute circulating concentrations of B-vitamins and their various forms (vitamers), following ingestion of realistic meals. This study compared the acute circulating B-vitamin and vitamer responses to either an energy-dense (ED) or a nutrient-dense (ND) breakfast meal, consumed in a randomized cross-over sequence, in older and younger adults (n = 15 and 15, aged 67.3 ± 1.5 and 22.7 ± 0.5 years (mean ± SEM), respectively). Eleven differing B-vitamins and vitamers were determined in plasma samples by ultra-high-performance liquid chromatography-tandem mass spectrometry, in the fasting and postprandial state (hourly for 5 h). While postprandial thiamine concentration increased following both meals, riboflavin increased only following a ND meal in both age groups. Many vitamins including nicotinic acid, pantothenic acid, pyridoxal, pyridoxamine, pyridoxal-5’phosphate, and 4-pyridoxic acid remained unaltered, and flavin mononucleotide (FMN), nicotinamide and nicotinuric acid concentrations reduced following both meals. Biological age and food composition had minimal impact on postprandial B-vitamin concentrations, yet the differences between the ED and ND meals for riboflavin highlight the importance of riboflavin intake to achieve adequacy.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

MDPI

Journal title

Nutrients

ISSN

2072-6643

Citation

Sharma, P., Gillies, N., Pundir, S., Pileggi, C. A., Markworth, J. F., Thorstensen, E. B., … Milan, A. M. (2019). Comparison of the acute postprandial circulating B-vitamin and vitamer responses to single breakfast meals in young and older individuals: preliminary secondary outcomes of a randomized controlled trial. Nutrients, 11(12), 2893. doi:10.3390/nu11122893

Report number

FBP 90468

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