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Circulatory amino acid responses to milk consumption in dairy and lactose intolerant individuals

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posted on 2023-05-03, 17:53 authored by Utpal Prodhan, Amber MilanAmber Milan, Aahana Shrestha, Mark Vickers, David Cameron-Smith, Matthew BarnettMatthew Barnett
Background/objectives Self-reported digestive intolerance to dairy foods is common. As dairy can be an important source of dietary protein, this study aimed to identify whether milk protein digestion is compromised in individuals with digestive intolerance. Subjects/methods Adult women (n = 40) were enroled in this double-blinded, randomised cross-over trial, with digestive symptoms characterised using a lactose challenge and self-reported digestive symptom questionnaire. Participants were classified as either lactose intolerant (LI, n = 10), non-lactose dairy intolerant (NLDI, n = 20) or dairy tolerant (DT, n = 10). In a randomised sequence, participants consumed three different kinds of milk (750 ml); conventional milk (CON), a2 Milk™ (A2M), and lactose-free conventional milk (LF-CON). Circulatory plasma amino acid (AA) concentrations were measured at baseline and every 30 min until 3 h post-ingestion. Results In all participants across all milk types, plasma AA concentrations (AUC0-180) increased after milk ingestion with no significant differences in responses observed between milk types or participants (P > 0.05), with the exception of the suppressed lysine response in the DT group following A2M ingestion, relative to the other two groups and milk types (P < 0.05). Conclusion Milk protein digestion, as determined by circulatory AAs, is largely unaffected by dairy- and lactose- intolerances.


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© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.


  • English

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Springer Nature

Journal title

European Journal of Clinical Nutrition




Prodhan, U. K., Milan, A. M., Shrestha, A., Vickers, M. H., Cameron-Smith, D., & Barnett, M. P. G. (2022). Circulatory amino acid responses to milk consumption in dairy and lactose intolerant individuals. European Journal of Clinical Nutrition, 76(10), 1415–1422.

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