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An independent validation study of loci associated with nematode resistance in sheep

journal contribution
posted on 2023-05-03, 21:52 authored by Orla Keane, James Hanrahan, Kathryn McRaeKathryn McRae, Barbara Good
Gastrointestinal nematode infection is a constraint on sheep production worldwide. Selective breeding programmes to enhance resistance to nematode infection are currently being implemented in a number of countries. Identification of loci associated with resistance to infection or causative mutations for resistance would enable more effective selection. Loci associated with indicator traits for nematode resistance has been identified in previous studies. In this study, Scottish Blackface, Texel and Suffolk lambs were used to validate the effects at eight genomic regions previously associated with nematode resistance (OAR3, 4,5, 7, 12, 13, 14, 21). No SNP was significantly associated with nematode resistance at the region-wide level but seven SNPs in three of the regions (OAR4, 12, 14) were nominally associated with trichostrongyle egg count in this study and six of these were also significant when fitted as single SNP effects. Nematodirus egg count was nominally associated with SNPs on OAR3, 4, 7 and 12.

History

Rights statement

©2018 Stichting International Foundation

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

Wiley

Journal title

Animal Genetics

ISSN

0268-9146

Citation

Keane, O. M., Hanrahan, J. P., McRae, K. M., & Good, B. (2018). An independent validation study of loci associated with nematode resistance in sheep. Animal Genetics, 49, 265–268. doi:10.1111/age.12649

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