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Altered dairy protein intake does not alter circulatory branched chain amino acids in healthy adults: a randomized controlled trial

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posted on 2023-05-03, 09:49 authored by Utpal Prodhan, Amber MilanAmber Milan, Eric Thorstensen, Matthew BarnettMatthew Barnett, Ralph Stewart, Jocelyn Benatar, David Cameron-Smith
Dairy, as a major component of a high protein diet, is a critical dietary source of branched chain amino acids (BCAA), which are biomarkers of health and diseases. While BCAA are known to be key stimulators of protein synthesis, elevated circulatory BCAA is an independent risk factor for type 2 diabetes mellitus. This study examined the impact of altered dairy intake on plasma BCAA and their potential relationship to insulin sensitivity. Healthy adults (n = 102) were randomized to receive dietary advice to reduce, maintain, or increase habitual dairy intake for 1 month. Food intake was recorded with food frequency questionnaires. Self-reported protein intake from dairy was reported to be reduced (-14.6 +/- 3.0 g/day), maintained (-4.0 +/- 2.0 g/day) or increased (+13.8 +/- 4.1 g/day) according to group allocation. No significant alterations in circulating free amino acids (AA), including BCAA, were measured. Insulin sensitivity, as assessed by homeostatic model assessment-insulin resistance (HOMA-IR), was also unaltered. A significant change in dairy protein intake showed no significant effect on fasting circulatory BCAA and insulin sensitivity in healthy populations.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Language

  • English

Does this contain Māori information or data?

  • No

Publisher

MDPI

Journal title

Nutrients

ISSN

2072-6643

Citation

Prodhan, U. K., Milan, A. M., Thorstensen, E. B., Barnett, M. P. G., Stewart, R. A. H., Benatar, J. R., & Cameron-Smith, D. (2018). Altered dairy protein intake does not alter circulatory branched chain amino acids in healthy adults: a randomized controlled trial. Nutrients, 10(10), 1510. doi:10.3390/nu10101510

Contract number

A21246

Job code

11590X09

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