Wool proteomics

The recent sequencing of the wool genome has considerably assisted the characterisation of the proteome of wool fibres. This has been achieved by the coupling of mass spectral sequence identification to the traditional two-dimensional gel electrophoresis, resulting in the identification of most of the protein spots on the two-dimensional map. More recently gel-free proteomic analysis of whole wool protein digests has resulted in an improved sequence coverage of some proteins and the identification of some isoforms of some of them.